The Cardiac Biomechanics Laboratory in the Department of Mechanical and Materials Engineering at the University of Denver is focused on applied and translational research in cardiovascular diseases. Despite significant scientific advances in the past two decades, cardiovascular disease is the primary cause of death in the industrialized world. To date, medical device industries have lagged behind other sectors of technology in adopting computational and experimental techniques in design and development. Our projects in the Cardiac Biomechanics Laboratory directed by Prof. Ali Azadani lie at the interface of engineering, medicine, and biology. We utilize modern engineering techniques to obtain greater insight into the complex pathways of cardiovascular diseases, and thereby develop new diagnostic and therapeutic devices.