Welcome to the DU Cardiovascular Biomechanics Lab

"To achieve all that is possible, we must attempt the impossible." John C. Maxwell


Image caption: Three-dimensional fluid-structure interaction computational simulation of a bioprosthetic heart valve.


The DU Cardiovascular Biomechanics Lab is focused on applied and translational research in the field of cardiovascular engineering. The scope of the research projects, directed by Dr. Ali Azadani, encompasses structural heart disease including transcatheter heart valve replacement and development of patient-specific therapeutic strategies. The team is currently well established in the field of cardiovascular biomechanics, and has expertise in computational modeling and simulation, including finite element (FE) analysis, computational fluid dynamic (CFD) simulations, and fluid-solid interaction (FSI) simulations. Furthermore, the lab is equipped with state-of-the-art equipment for in vitro testing of biomaterials and medical devices. In addition to standard equipment, the lab has a custom-built pulse duplicator system for in vitro testing of surgical and transcatheter heart valves, high-resolution particle image velocimetry (PIV) system, biaxial stretching system, 3D cardiovascular ultrasound system, 3D laser scanner, and access to a 3D high-resolution digital image correlation (DIC) system. Strong collaborations exist between his lab and other research groups in the U.S. and worldwide. Moreover, the lab has a strong record of federal, industrial grant, and foundation support.

Below please find a brief summary of our research projects.  For more details, please see the publication list.

Fluid-Solid Interaction Simulation


Multiscale Modeling and Analysis


Finite Element Analysis


Mechanical Characterization of Soft Tissue by Planar Biaxial Testing


Fluid Dynamic Characterization by Particle Image Velocimetry


Deformation Measurements of Soft Tissue by Digital Image Correlation


In-Vitro Testing and Assessment


Ex-Vivo Testing and Evaluation


Cardiovascular Tissue Engineering


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